Levi's Stadium will play host to Monday's Round 7 NFL game between Indianapolis Colts and San Francisco 49ers. The game kicks off at 11:21 am with San Francisco 49ers heading into the game as favourites with the bookmakers. Continue reading for our in-depth preview of the Indianapolis Colts vs. San Francisco 49ers game and give you our free tips and bets.
When: Monday October 25, 2021 at 11:21 am
Where: Levi's Stadium
Bet: Bet On This Match HERE
Indianapolis Colts vs San Francisco 49ers Odds
Indianapolis Colts vs San Francisco 49ers Preview
The 2-3 Niners meet the 2-4 Colts on Sunday Night Football in what is arguably one of the toughest games to pick this week.
Indy bounced back from an overtime loss to Baltimore with a huge blowout win over the Texans last week, while the Niners are in the midst of a three-game skid.
Jimmy Garoppolo is a chance at returning this week for San Francisco, a welcome sign with Trey Lance struggling under centre two weeks ago in the loss to Arizona.
Carson Wentz, meanwhile, has started to take some big steps in the right direction, but I fully expect to see the Colts running the ball down San Francisco’s throat given how vulnerable they’ve looked defensively on the ground.
Jonathan Taylor has emerged as one of the most lethal young running backs in the league this year, and that was certainly the case last week when he put up 145 yards on Houston.
San Francisco is averaging over 100 rushing yards to opponents so far, and with the Colts winning each of their last four games against the Niners, I think a Same Game Multi is in order.
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Indianapolis Colts vs San Francisco 49ers Tip
We're tipping San Francisco 49ers to win at $1.55 odds.